Bandim Health Project (BHP) has made several groundbreaking observations. The most important is undoubtedly that the most widely used health interventions to children in low income countries, vaccinations and vitamin A supplements, may have much more dramatic effects than previously thought.
Live attenuated vaccines like the tuberculosis vaccine (BCG) and measles vaccine stimulate the immune system and protect against a wide range of other diseases. Worrying diphtheria-tetanus-pertussis (DTP) vaccine seems to increase mortality from other diseases. These nonspecific vaccine effects are strongest for girls. There are also sex differences in the response to vitamin A supplements, whereas it often is beneficial for boys, several studies have shown a strong negative effect for girls.
These are very important observations for two reasons. Firstly, it means that we probably can reduce mortality far more by using vaccines and vitamin A supplements, so they get the optimal beneficial effects. Secondly, they contradict the common views of vaccines and vitamin A supplements, and our understanding that boys and girls should receive the same vaccines and supplements at the same time. It is thus represents a very important scientific achievement, a paradigm shift.
The research at the BHP has been published more than 600 articles in estimated international journals. In an external evaluation of DANIDA-funded international health projects in 2007 the BHP was the most productive. In a bibliographic review conducted by the Indepth Network, the BHP was twice as productive as any other health project.
The research subjects below are taken from the book
Bandim Health Project 2003-2008. Improving Child Survival.
Download the book: Bandim Health Project 2003-2008
You can download each section of the book according to the listed research subjects by clicking the pdf links.
13 Non-specific effects of vaccines are important (Peter Aaby)
14 Survival bias (Henrik Ravn) 15 BCG at birth: Non-specific beneficial effects (Adam Roth/Peter Aaby)
16 Oral polio vaccine at birth (Najaaraq Lund/Christine Stabell Benn)
17 Revaccination with BCG (Adam Roth/Peter Aaby)
18 High-titre measles vaccine: The sequences of vaccinations (Peter Aaby)
19 Early measles vaccination: Targeted and non-targeted effects (Cesario Martins/Peter Aaby)
20 Sex-differential and non-specific effects of inactivated vaccines (Peter Aaby)
21 Out-of-sequences vaccinations (Peter Aaby)
22 Non-specific effects of smallpox vaccine in Guinea-Bissau (Adam Roth)
23 Non-specific effects of smallpox vaccine and BCG: Taking the observations to Denmark (Adam Roth)
24 Breats feeding and improved child health: Effect or confounding (Marianne Jakobsen)
25 Vitamin A and vaccines (Christine Stabell Benn) 26 Neonatal vitamin A supplementation (Christine Stabell Benn)
27 Redosing with vitamin A (Ane Baerent Fisker/Dorthe Christoffersen)
28 Immunological studies: Vitamin A and non-specific effects of vaccines (Mathias Jul Jorgensen)
29 Re-introducing sex-differential treatment of children (Sofie Biering-Sorensen/Christine Stabell Benn)
Childhood infections and management
3 Rotavirus (Thea Fischer)
4 Long-term consequences of Chickenpox in Guinea-Bissau (Anja Poulsen)
5 Measles infection and prophylactic antibiotics (May-lill Garly)
6 Malaria treatment and development of resistance (Poul-Erik Kofoed)
7 Is malaria disappearing (Amabelia Rodriques)
8 Respiratory syncytial virus: Taking the oberservations to Denmark (Lone Graff Stensballe)
The health care system
9 Improving the hospital care (Amabelia Rodriques)
10 Hypothermia of newborns is associated with excess mortality (Morten Sodemann)
11 Maternal vulnerability and child mortality (Morten Sodemann)
12 Knowing a medical doctor may save childrens lives in low resource settings (Morten Sodemann)
HIV and Tuberculosis
32 Retroviral epidemics in Guinea-Bissau: HIV-1, HIV-2, and HTLV (Zacarias da Silva/Ines Oliveira)
33 HIV-1, HIV-2, and HTLV-I:DUAL INFECTIONS (Birgitte Holmgren)
34 Clinical tuberculosis studies (Christian Wejse)
35 TB-negative individuals: Using SuPAR to identify individuals with high mortality risk (Paulo Rabna/Jesper Eugen-Olsen)
36 Too many chefs in Africa (Morten Sodemann)
30 Maternal mortality: reducing severe postpartum haemorrhage (Lars Høj)
31 Low birth weight delivery and maternal mortality (Karen Rokkedal/Peter Aaby)
Last revised 30 March 2015