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Evaluation of the effect of vaccines on overall health in Danish children

The first results from Signe Sørups Postdoc studies on Danish children show that oral polio vaccine is associated with lower rate of admissions with infections.

Signe Sørup is conducting a Postdoc project with the aim to evaluate the effect of vaccines on the overall health in Danish children. The project has recently been described further on the scientific news website videnskab.dk. The first results from the project have been published in Open Forum Infectious Diseases and show that Danish children vaccinated with the live oral polio vaccine (OPV) had 15 % lower risk of admissions with non-polio infections compared with Danish children who had only received the inactivated vaccine against diphtheria, tetanus, pertussis, polio, and Haemophilus influenzae type b. The results on any type of infection was mainly explained by a 27% lower risk of admissions with lower respiratory infections. There was no difference in risk of admissions with non-polio infections between OPV and the live measles, mumps, and rubella vaccine.

Oral polio vaccine was phased out in Denmark in 2001

Until 2001 OPV was included in the Danish vaccination programme in a three dose schedule at 2, 3, and 4 years of age. The study is a nationwide cohort study including 137,403 Danish children born in 1997 till 1999, who were the last cohorts eligible for OPV. The study was based on information from the Danish registers and thus the analyses are controlled for range of factors related both to vaccinations and admissions with infections.

Links

Sørup S, Stensballe LG, Krause TG, Aaby P, Benn CS, Ravn H. Oral Polio Vaccination and Hospital Admissions With Non-Polio Infections in Denmark: Nationwide Retrospective Cohort Study. Open Forum Infect Dis. 2015 Dec 17;3(1):ofv204. doi: 10.1093/ofid/ofv204. eCollection 2016

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Boas, Anders. Rækkefølge af vacciner kan have afgørende betydning for børns helbred. Videnskab.dk 18.05.2016

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