Neonatal vitamin A supplementation associated with increased atopy in girls

23 June 2015

In 2013 we conducted a follow-up study on children who at birth had been randomised to neonatal vitamin A supplementation (NVAS) or placebo. In the children now aged 8-10 years, the effect of NVAS on atopy was analysed with skin prick tests and interviews on symptoms of atopic disease. NVAS had no overall effect on atopy among the 1430 children with a valid test, but the effect was sex-differential; NVAS significantly increased the risk of atopy in girls (RR 1.78 [1.17-2.72]) whereas the tendency was opposite in boys. NVAS also increased the risk of wheezing in girls, but not in boys.

Among BCG vaccinated children having a scar was associated with reduced mortality

18 June 2015

In rural Guinea-Bissau we found that only 52% of 15,911 BCG-vaccinated children had developed a vaccination scar. In the scar positive group mortality was 52% (10-74%) lower than in the scar negative group during the first year of life and 26% (4-44%) lower during the first 5 years of life.