23 June 2015
In 2013 we conducted a follow-up study on children who at birth had been randomised to neonatal vitamin A supplementation (NVAS) or placebo. In the children now aged 8-10 years, the effect of NVAS on atopy was analysed with skin prick tests and interviews on symptoms of atopic disease. NVAS had no overall effect on atopy among the 1430 children with a valid test, but the effect was sex-differential; NVAS significantly increased the risk of atopy in girls (RR 1.78 [1.17-2.72]) whereas the tendency was opposite in boys. NVAS also increased the risk of wheezing in girls, but not in boys.